Hypersecretion of growth hormone in childhood
IGF-1, or Insulin-Like Growth Factor 1 , has a major role in both childhood growth and anabolism (muscle and tissue growth) in adults. In children, IGF-1 is not an essential regulator of development. It is believed that both growth and maintenance of muscle function are dependent upon the amount and activity of IGF-1, however the importance of IGF-1 in adults is more ambiguous, anabolic steroids cycles for beginning bodybuilders. In adult humans, no effects of increased IGF1 have been observed in terms of muscle mass. On the contrary, IGF-1 has been shown to be beneficial in growth response in adult mice due to its immunomodulatory properties (insulin-like growth factor 1), hypersecretion of growth hormone in childhood. Increased circulating IGF-1 levels in obese subjects have been found in relation to insulin resistance and/or muscle tissue hypoallergenic properties (the use of drugs to suppress circulating IGF-1 lowers the muscle mass and thus muscle mass is increased in response to the insulin/IGF-1 hormone), but in a more limited fashion, anabolic steroids and sleep. Thus, the most critical role of IGF-1 in humans is to inhibit the accumulation of lipid and protein within the cell, promoting growth. The fact that most studies on the effects of increased IGF-1 in humans or animals have involved the use of IGF-1 in the treatment of cancers (although animal models are of relevance) may be due to the fact that IGF-1 is rapidly acting and has been known to have various effects on the growth and development of different cell types.
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